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Although there is substantial evidence supporting the role of PDE1B and PDE10A inhibition in schizophrenia, designing highly selective inhibitors for PDE1B and PDE10A has proven challenging due to the high degree of structural similarity between the catalytic sites of these enzymes
Unlike DSIP, Z-drugs have well-established efficacy but carry risks of tolerance, dependence, cognitive impairment, and residual daytime sedation
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Jared Meacham, PhD., RD, CSCS Read more about what does magnesium do for your body, here
10.1146/annurev.nu.06.070186.002053 Annu Rev Nutr
